Fig. 1
From: Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial
Identifying eQTLs in SLE patients. a Clinical trial structure and sampling strategy for the individuals used for eQTL analysis. The samples available are summarized in Table 1. b Number of eQTL genes identified using a linear model (left) and a linear mixed model (right). For the linear model, we used the first available time point for each individual (week 0 sample for n = 152, week 12 sample for n = 5). c Volcano plot of eQTL effects for the most significantly associated SNP for each gene (red color indicates p < 8.5 × 10− 9). d Concordance of SLE eQTL effects (p < 8.5 × 10− 9) with eQTLs observed in the BIOS cohort [11] of healthy individuals (FDR < 0.05). Each point represents the most significant SNP-gene pair for the SLE eQTL