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Fig. 6 | Genome Biology

Fig. 6

From: Chromosome evolution at the origin of the ancestral vertebrate genome

Fig. 6

Comparison between the pre-1R karyotype (top) composed of 17 chromosomes and the human karyotype (middle). The 8282 known human descendent genes of pre-1R genes are drawn at their position in the human genome with the color of their pre-1R ancestral chromosome. The position of 12 extant clusters (4 HOX, 4 FOX and 4 MHC) descending from a single clusters in pre-1R chromosomes are indicated by a black circle and a 2-character identifier (M1, M2, M3, M4 for MHC clusters, F1, F2, F3, F4 for FOX clusters, HA, HB, HC, HD for HOX clusters). A second human karyotype (bottom) shows, in a white-to-red scale, the number of ohnologs in windows of 50 genes positioned every 10 genes. Open circles denote the position of HOX clusters. Human chromosomes are drawn to scale, in Mb. Pre-1R chromosomes are drawn as in Fig. 5, in proportion to the number of genes assigned to each. The order of genes in pre-1R chromosomes being unknown, the positions of the 3 pre-1R gene clusters within their chromosome are arbitrary

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