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Fig. 2 | Genome Biology

Fig. 2

From: Chromosome evolution at the origin of the ancestral vertebrate genome

Fig. 2

Identification of ohnolog pairs in the ancestral Amniota genome. (a) Comparison between five lists of ohnolog pairs in Amniota. Left: a Venn diagram of the sets of ohnolog pairs from five lists: list A (this study), list B [8] and the three lists C [9]. The numbers of pairs at the intersections of the lists are indicated. Right: a Venn diagram of the sets of ohnolog genes from the same lists as above. The overlap between the lists of ohnolog genes is higher than between the lists of pairs because the latter contain different pairs between the same genes. For example, two pairs G1-G2 and G1-G4 are in different lists (no overlap between lists) but gene G1 is common to both lists (1 gene overlap; see (b) for a graphical illustration). The surface of the circles and their intersection are roughly proportional to the number of genes pairs or genes of each list. (b) Schematic example of ohnolog pair selection. Step 1: from the initial list of 1273 gene pairs (black area in Venn diagram), 2 pairs involve 3 genes G1, G2, and G3, each on a different CAR. Step 2: pairs from a new sub-list are considered, a new gene pair G1-G4 is added to the network. Gene G4 is on a fourth CAR. Step 3: A new list is considered, a new pair is identified (G4-G5) but G5 is on a fifth CAR so pair G4-G5 is discarded. Step 4: a new list is considered, a pair G4-G3 supporting the network is identified

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