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Fig. 7 | Genome Biology

Fig. 7

From: Holo-Seq: single-cell sequencing of holo-transcriptome

Fig. 7

miRNA-mRNA regulatory modules and super-enhancer activity analysis of hepatocellular carcinoma (HCC) single cells. a Identified miRNA-mRNA regulatory modules related to tumorgenesis. b Correlation heat map of the genome-wide super-enhancer activity of 32 HCC single cells (Left panel). The cells are ranked in the same order as Fig. 6a. Three super-enhancer-based cell subpopulations (SE-subpopulation) are identified. Right panels is the relative expression heat map of the gene sets related to mitochondrial activity, oncogenic signals pathways, tumor suppressor miRNAs, and oncomiRs of 32 HCC single cells

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