Table 2 Lineage restricted PFAM-A domains

Present in ANEMONE not in coral

DUF3445

Protein of unknown function (DUF3445)

Present in COMPLEX not in robust corals

BCL_N*

BCL7, N-terminal conserver region

DUF853

Bacterial protein of unknown function (DUF853)

SR-25*

Nuclear RNA-splicing-associated protein

IF3_N

Translation initiation factor IF-3, N-terminal domain

Toxin_R_bind_N*

Clostridium neurotoxin, N-terminal receptor binding

CHZ

Histone chaperone domain CHZ

DUF4557

Domain of unknown function (DUF4557)

DUF455

Protein of unknown function (DUF455)

Nucleoplasmin*

Nucleoplasmin

MotA_ExbB

MotA/TolQ/ExbB proton channel family

CBM_11*

Carbohydrate binding domain (family 11)

COX7a

Cytochrome c oxidase subunit VIIa

Microtub_assoc*

Microtubule associated

PNMA

PNMA

Drc1-Sld2*

DNA replication and checkpoint protein

SLBB

SLBB domain

Prefoldin_3*

Prefoldin subunit

5-nucleotidase

5′-nucleotidase

CutA1*

CutA1 divalent ion tolerance protein

MacB_PCD

MacB-like periplasmic core domain

DUF2414*

Protein of unknown function (DUF2414)

Glyco_trans_4_2

Glycosyl transferase 4-like

Dynein_IC2*

Cytoplasmic dynein 1 intermediate chain 2

HtrL_YibB

Bacterial protein of unknown function (HtrL_YibB)

MIF4G_like*

MIF4G like

Glyco_transf_17

Glycosyltransferase family 17

TAN*

Telomere-length maintenance and DNA damage repair

DUF1762

Protein of unknown function (DUF1762)

DUF2201

VWA-like domain (DUF2201)

FAM216B

FAM216B protein family

MGC-24*

Multi-glycosylated core protein 24 (MGC-24)

Resistin

Resistin

Hint_2

Hint domain

DUF3598

Domain of unknown function (DUF3598)

Mem_trans*

Membrane transport protein

PDH

Prephenate dehydrogenase

DUF4606*

Domain of unknown function (DUF4606)

YbjQ_1

Putative heavy-metal-binding

CBM_20

Starch binding domain

IF2_N

Translation initiation factor IF-2, N-terminal region

IlvN

Acetohydroxy acid isomeroreductase, catalytic domain

Present in CORAL not in anemone

OLF

Olfactomedin-like domain

Present in ROBUST not in complex corals

RAG1

Recombination-activation protein 1 (RAG1)

LRRNT

Leucine rich repeat N-terminal domain

DUF2341

Domain of unknown function (DUF2341)

Myb_DNA-bind_3

Myb/SANT-like DNA-binding domain

Toxin_60

Putative toxin 60

HTH_19

Helix-turn-helix domain

HisG

ATP phosphoribosyltransferase

Parvo_coat_N

Parvovirus coat protein VP1

Glt_symporter*

Sodium/glutamate symporter

ScpA_ScpB

ScpA/B protein

NTPase_I-T*

Protein of unknown function DUF84

MFS_3

Transmembrane secretion effector

XG_Ftase*

Xyloglucan fucosyltransferase

BBE

Berberine and berberine like

Phospholip_A2_2*

Phospholipase A2

LBR_tudor

Lamin-B receptor of TUDOR domain

Polysacc_lyase

Polysaccharide lyase

HATPase_c_4

ATP-dependent DNA helicase recG C-terminal

PRA-CH

Phosphoribosyl-AMP cyclohydrolase

PSDC

Phophatidylserine decarboxylase

Sigma70_r4_2*

Sigma-70, region 4

STAG

STAG domain

HTH_Tnp_Tc3_2*

Transposase

GH3

GH3 auxin-responsive promoter

IGPD*

Imidazoleglycerol-phosphate dehydratase

Glutaminase

Glutaminase

EURL

EURL protein

Smoothelin

Smoothelin cytoskeleton protein

Histidinol_dh

Histidinol dehydrogenase

DUF1982

Domain of unknown function (DUF1982)

Hexapep_2*

Hexapeptide repeat of succinyl-transferase

MRP-L28

Mitochondrial ribosomal protein L28

DUF4094

Domain of unknown function (DUF4094)

Tocopherol_cycl

Tocopherol cyclase

HisG_C

HisG, C-terminal domain

Sec39

Secretory pathway protein Sec39

DUF1864

Domain of unknown function (DUF1864)

DUF3496

Domain of unknown function (DUF3496)

Phage_T7_tail

Phage T7 tail fibre protein

DUF4613

Domain of unknown function (DUF4613)

PRA-PH*

Phosphoribosyl-ATP pyrophosphohydrolase

HK

Hydroxyethylthiazole kinase family

Lipase_GDSL_3

GDSL-like Lipase/Acylhydrolase family

Macro_2

Macro-like domain

DUF72

Protein of unknown function DUF72

SRP9–21

Signal recognition particle 9 kDa protein (SRP9)

PMT_2

Dolichyl-phosphate-mannose-protein mannosyltransferase

STAT_int

STAT protein, protein interaction domain

CNPase

2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNP or CNPase)

UPF0066

Uncharacterised protein family UPF0066

Tnp_zf-ribbon_2

DDE_Tnp_1-like zinc-ribbon

Eno-Rase_NADH_b

NAD(P)H binding domain of trans-2-enoyl-CoA reductase

CR6_interact

Growth arrest and DNA-damage-inducible proteins-interacting protein 1

BRCA-2_OB3

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3