Fig. 2
From: CRISPhieRmix: a hierarchical mixture model for CRISPR pooled screens
a Receiver operator curves for gene scores computed by CRISPhieRmix, the Mann-Whitney test, and MAGeCK MLE on the Rosenbluh CRISPRi simulated data. The diagonal line y=1−x indicates performance by random chance. b The corresponding estimated false discovery rates (x-axis) plotted against the corresponding empirical false discovery rates (y-axis). The diagonal line y=x indicates perfect control of the false discovery rate. c and d are the same as a and b, respectively, but on the Rosenbluh CRISPRko simulated data