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Fig. 4 | Genome Biology

Fig. 4

From: Reduced intrinsic DNA curvature leads to increased mutation rate

Fig. 4

Changing the intrinsic DNA curvature in URA3 leads to altered mutation rate. a The distribution of the average intrinsic DNA curvature of genes in the yeast genome. The intrinsic DNA curvatures of five synonymous variants of URA3 are indicated by arrows. S1 and S2 (G1 and G2) are variants with a smaller (greater) intrinsic DNA curvature. b The schematic description of the experimental procedure for measuring the relative mutation rate of URA3 variants. c Reduction of intrinsic DNA curvature leads to an increase in the mutation rate of URA3. Outliers are not shown. P values were calculated from the one-tailed Mann-Whitney U test. d Similar to c, in a mismatch repair-deficient msh2 strain

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