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Fig. 2 | Genome Biology

Fig. 2

From: Reduced intrinsic DNA curvature leads to increased mutation rate

Fig. 2

Intrinsic DNA curvature is negatively correlated with mutation rate. a Correlation between mutation rate and the value of each DNA feature in sliding windows (window length L). These features include GC content (orange), thermodynamic characteristics (purple), groove properties (green), intra- and inter-base pair DNA shape features (cyan), and integrated DNA shape features (blue). Intra- and inter-base pair DNA shape features are shown in cartoons, where a square represents a base and a rectangle represents a base pair. P values were calculated from the Spearman’s correlation. b, c Example scatter plots of URA3 (b) and of CAN1 (c). Each dot represents a region of length L (= 100 bp). d The average intrinsic DNA curvature of DNA regions surrounding the 882 observed mutation sites (red arrow) was significantly smaller than the random expectation (histogram showing 1000 permutations) in the yeast genome. P value was calculated with a permutation test

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