Fig. 1
From: Reduced intrinsic DNA curvature leads to increased mutation rate
The mutational landscape of URA3. a A schematic description of the experimental design. Mutations were accumulated in SC liquid medium and ura3 mutants were selected on 5-FOA plates. b Mutational landscape of all potential nonsense mutation sites, which were defined as sites where a point mutation can result in a stop codon. Each bar represents a potential nonsense mutation site. c The observed (red arrow) and expected (histogram showing 1000 permutations) standard deviation of the numbers of nonsense mutations on all potential nonsense mutation sites of URA3