Fig. 4

Interaction between STAT1 binding and accumulation of H3K9K14ac (a–c) and H3K4me3 (d, e). a For all genomic regions bound by STAT1 at 2 h after LPS stimulation, mean H3K9K14ac signals are shown over time. Left: profile of mean values (y axis) over time in bins of 100 bps in function of distance (x axis) to the TF binding site. Right: mean values (y axis) summed over the region − 2 to + 2 kb over all bound regions, over time (x axis). The red arrow indicates the time at which these regions become bound by STAT1. b The fraction of promoters with increases in H3K9K14ac at each time point after stimulation (x axis). Blue, the 409 promoters bound by STAT1 at time 2 h; red, 23,964 promoters not bound by STAT1 at any time point. c As in b, for 378 enhancer regions bound and 33,693 not bound by STAT1. d As in a, for H3K4me3 at the genomic regions bound by STAT1 2 h after LPS stimulation. e As in b, for increases in H3K4me3 at 409 promoters bound by STAT1 and 23,964 promoters not bound by STAT1