Fig. 1
From: omniCLIP: probabilistic identification of protein-RNA interactions from CLIP-seq data
Illustration of omniCLIP peak calling. Shown on the (left) is peak calling for a lowly expressed genes with strong RNA binding protein (RBP) RNA-binding and on the (right) a highly expressed gene with weak RBP RNA-binding. During peak calling, local background coverage is taken into account to correct for confounding by local effects or biases. Furthermore, overall the RNA abundance is estimated and accounted for. This allows better ranking peaks with identical local coverage by sharing of information along the transcript, as illustrated for the leftmost peaks in both genes