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Table 2 Predicting LBC1936 phenotypes using methylation and genetic predictors for health and lifestyle factors

From: Epigenetic prediction of complex traits and death

Trait DNAm score (%) Polygenic score (%) DNAm + polygenic (%)
BMI (kg/m2) 12.5 10.1 19.7
Alcohol (units per week) 12.5 0.7 13.0
Smoking (current/ever/never) 60.9 2.8 61.4
Educational attainment (years) 2.5 4.0 5.9
Total cholesterol (mmol/L) 2.7 1.1 3.6
HDL cholesterol (mmol/L) 15.6 1.9 17.3
LDL with remnant cholesterol (mmol/L) 0.6 1.8 2.4
Total:HDL cholesterol ratio 4.5
Waist-to-hip ratio
Body fat (%)
  1. For each trait, the proportion of phenotypic variance explained is presented for DNAm score, polygenic score, and combined DNAm + polygenic scores for health and lifestyle factors