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Table 2 Predicting LBC1936 phenotypes using methylation and genetic predictors for health and lifestyle factors

From: Epigenetic prediction of complex traits and death

Trait

DNAm score (%)

Polygenic score (%)

DNAm + polygenic (%)

BMI (kg/m2)

12.5

10.1

19.7

Alcohol (units per week)

12.5

0.7

13.0

Smoking (current/ever/never)

60.9

2.8

61.4

Educational attainment (years)

2.5

4.0

5.9

Total cholesterol (mmol/L)

2.7

1.1

3.6

HDL cholesterol (mmol/L)

15.6

1.9

17.3

LDL with remnant cholesterol (mmol/L)

0.6

1.8

2.4

Total:HDL cholesterol ratio

4.5

–

–

Waist-to-hip ratio

–

–

–

Body fat (%)

–

–

–

  1. For each trait, the proportion of phenotypic variance explained is presented for DNAm score, polygenic score, and combined DNAm + polygenic scores for health and lifestyle factors