Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis

Table 2 Estimated overall effect size and p values for continuous scores on molecular, histopathological, and clinical variables from fixed effects model

Variable	Continuous score	Effect size	p value
CMS1 subtype	PCSS1	0.82	3E-55
CMS1 subtype	PCSS2	− 2.55	1E-129
CMS2 subtype	PCSS1	− 2.00	2E-156
CMS2 subtype	PCSS2	0.76	7E-60
CMS3 subtype	PCSS1	− 0.57	2E-28
CMS3 subtype	PCSS2	− 0.75	6E-56
CMS4 subtype	PCSS1	1.72	2E-130
CMS4 subtype	PCSS2	1.75	4E-106
MSI	PCSS1	0.76	1E-31
MSI	PCSS2	− 1.68	5E-71
Right location	PCSS1	0.087	0.09
Right location	PCSS2	− 0.23	1E-04
Late stage	PCSS1	0.16	0.002
Late stage	PCSS2	0.24	6E-06
High grade	PCSS1	0.33	3E-05
High grade	PCSS2	− 0.30	7E-05
Disease recurrence or death	PCSS1	0.23	5E-05
Disease recurrence or death	PCSS2	0.19	0.001

The effect size statistic is log hazard ratio for disease recurrence or death and log odds ratio for all other variables. These estimates are not sensitive to fixed vs random effects modeling (Additional file 5: Table S4). Statistics for individual datasets, including I² statistics, are also provided in Additional file 5: Table S4

ISSN: 1474-760X