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Fig. 4 | Genome Biology

Fig. 4

From: Interaction between the microbiome and TP53 in human lung cancer

Fig. 4

Mutations in TP53 associated with abundance of taxonomic signature specific to squamous cell lung tumors. a Heat map of genus-level abundance in NCI-MD data colored by mutation status, TP53 wild-type or mutated, smoking, and histological subtype in all lung tumor samples. b Heat map of genus-level abundance from TCGA data in all tumors colored by mutation status, TP53 wild-type or mutated, smoking, and histological subtype. c, d Fold change in mean abundance of SCC-associated taxa in NCI-MD or TCGA tissues comparing TP53 mutated to wild-type. Test of significance is Mann–Whitney. Fold change among all taxa in (d) are significant after FDR correction < 0.01. (NCI-MD; SCCwt = 11, SCCmut = 35 and TCGA; SCCwt = 59, SCCmut = 118)

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