Fig. 1
From: Interaction between the microbiome and TP53 in human lung cancer
The bacterial profile and diversity of the lung microbiome in non-diseased and cancerous tissues. a 16S rRNA gene sequences from non-diseased lung (ImA or HB; top), non-tumor adjacent (NT) and tumor (T) assigned to OTUs or proportional abundance of metatranscriptomic sequences (TCGA; bottom) at the phylum level showing the most dominant taxa for each tissue type. b Alpha diversity between non-diseased lung tissue (ImA and HB) non-tumor adjacent (NT) and tumors from 16S rRNA gene sequencing using Chao1 (richness) or inverse Simpson index. *p < 0.05, **p < 0.01. Test of significance is Mann–Whitney. PCoA plots from NCI-MD study of tissue microbiome beta-diversity colored by (c) all tissue types, (d) cancer cases, and (e) histological subtype; and from TCGA study of (f) cancer cases and (g) histological subtype. ImA immediate autopsy, HB hospital biopsy