Fig. 3
From: Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture
Fraction of 3n divisible exon and intron lengths. a Percentage of introns with 3n divisible lengths that were classified as IR-negative (x-axis) and IR-positive (y-axis) in each species with more than ten IR-positive introns. b Percentage of exons with 3n divisible lengths that were classified as ES-negative (x-axis) and ES-positive (y-axis) in each species with more than ten ES-positive exons. Dots are color-coded according to enrichments in either direction (3n bias in blue, anti-3n bias in red) as per Fisher’s exact test (p < 0.01; Additional file 1: Figure S9). c Percentage of ES-positive exons that are 3n (y-axis) with respect to the percentage of genes with ES-positive exons (x-axis), per species. Shading colors grouping the most representative species for certain eukaryotic groups (bilaterians, non-bilaterians, and other eukaryotes) are provided for reference. d Fraction of 3n exons in ES events (rES = 10–90%, grey bar segment) compared to a subset of high-frequency events (rES = 30–70%), highlighting increases (blue) or decreases (red) of the 3n fraction. In panels d and e, asterisks indicate significant 3n biases in ES-positive compared to ES-negative exons, as per Fisher’s exact test (p < 0.01; Additional file 1: Figure S9). In all panels, only species with more than ten exons in all categories are included. e Fraction of 3n exons in ES events (grey bar segment) compared to a subset of genes with above-median expression (cRPKM) and gene length (‘high constraint’), highlighting increases (blue) or decreases (red) of the 3n fraction