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Fig. 2 | Genome Biology

Fig. 2

From: Origin of exon skipping-rich transcriptomes in animals driven by evolution of gene architecture

Fig. 2

Frequency of AS in eukaryotes. a Distribution of ES frequencies across 65 eukaryotic transcriptomes. Each box plot represents the distribution of ES frequencies (FES,sp) in a given species (as percentage), drawn from mapping up to 10,000 RNA-seq reads to junctions from 100 exon triplets, in up to 100 independent subsets (see “Methods” and Additional file 1: Figure S3). b Log-ratio of mean FES,sp (for ES) over mean FIR,sp (for IR) in each species. FIR,sp distributions in Additional file 1: Figure S6. c–f Comparisons of ES frequencies among phylogenetically related eukaryotic groups with a focus on animals, holozoans, and plants. Group-level ES distributions obtained by pooling FES,sp of multiple species. For each set of comparisons, we report the pooled distributions’ box plots (left) and empirical cumulative distributions (right). Selected p values are reported, corresponding to pairwise one-sided Kolmogorov-Smirnov two-sample tests (full report in Additional file 1: Figure S9), and should be interpreted as follows: green arrows indicate that the group of origin has significantly higher FES,sp than others; grey bidirectional arrows indicate that no significant differences are observed in any direction at the given threshold

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