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Fig. 2 | Genome Biology

Fig. 2

From: Homeobox oncogene activation by pan-cancer DNA hypermethylation

Fig. 2

Pan-cancer differentially methylated UMRs. a The statistical framework for the identification of pan-cancer hypermethylated or hypomethylated UMRs. Red (blue) lines represent significant methylation increase (decrease) (p value <‚ÄČ0.001corrected by BH) in each tumor type and in pan-cancer. Tumors types include bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), glioblastoma multiforme (GBM), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), stomach adenocarcinoma (STAD), and uterine corpus endometrial carcinoma (UCEC). b Pan-cancer differential UMRs found in individual tumor type. c Percentage of human reference canyons/cUMRs that are either hypermethylated or hypomethylated in pan-cancer. d DNA methylation genome browser tracks of a pan-cancer hyper-methylated canyon around homeobox gene HOXB13

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