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Fig. 8 | Genome Biology

Fig. 8

From: Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

Fig. 8

Rewiring of promoter interactions in aged pre-B cells. Genome browser representation of interactions from the Irs1 (a) and Ccnd3 (b) promoters in young and aged pre-B cells. Both are examples of genes whose expression is downregulated upon aging. Shown are all interactions with a CHiCAGO score above the significance threshold of 5 that lie within the genomic region depicted. For ATAC-seq and ChIP-seq tracks, read counts were quantified over 100-bp windows and normalized with size factors from DESeq2 analysis of MACS peaks. For a given locus and chromatin mark, young and aged are displayed on the same scale. Shading indicates interactions that are lost upon aging (blue) or that display a decrease in H3K27ac enrichment at the PIR (grey)

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