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Fig. 4 | Genome Biology

Fig. 4

From: Genome organization and chromatin analysis identify transcriptional downregulation of insulin-like growth factor signaling as a hallmark of aging in developing B cells

Fig. 4

Age-associated changes in chromatin accessibility and H3K27me3 in pre-B cells. a DESeq2 analysis of read counts over ATAC-seq peaks in pre-B cells reveals 4 regions with increased chromatin accessibility and 10 regions with reduced accessibility upon aging. Three of the latter overlap with the Irs1 gene; two of these are illustrated in the insert. b DESeq2 analysis of read counts over H3K27me3 peaks in pre-B cells reveals only two regions with a significant alteration in this repressive mark upon aging. The first overlaps with the Irs1 promoter region, where H3K27me3 is significantly increased. The second overlaps with a potential regulatory region/alternative promoter for the Let-7b/c2 precursor, where there is a significant decrease in H3K27me3. Both are illustrated in inserts. For inserts, median normalized reads for aged and young are shown on the same scale. Black bars beneath the plots indicate the peak locations

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