Fig. 5

Spatial dynamics can contain additional information about gene expression changes beyond signal density changes. Gene expression change is plotted as function of ChIP-seq signal density change after loess smoothing for each predicted ChromTime dynamic for a H3K4me2 dynamics in T-cell development in mouse [17] and b H3K4me3 dynamics in stem cell reprogramming in human [24] (Additional file 2: Supplementary methods). Peaks of each type of dynamics were pooled from all time points in each dataset for this analysis. Peaks with asymmetric dynamics E/S and S/E were pooled together in the “E-S” group. Similarly C/S and S/C peaks were pooled in the “C-S” group. The total number of peaks in each group is shown in parenthesis. In both systems, for a range of signal density changes, peaks with the same signal density change associated with different gene expression changes depending on the predicted spatial dynamic. Shaded regions represent 95% confidence intervals