Fig. 5From: Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germlineThe impact of loop anchor points on tumour and population variation. a Average SNV somatic mutations based on ICGC pan-cancer tumour sequencing data and b the average number of polymorphic segregating sites within 500Â kb of LAPs and HSs. LAPs are subdivided into those that do or do not overlap recombination HSs, respectivelyBack to article page