Fig. 2

Loop anchor points are susceptible to somatic double-strand breaks. a DNA double-strand break density in the NHEK cell line, within 500 kb of NHEK LAPs and recombination HSs. b Predicted quadruplex structure forming sequence density within 500 kb of the union set of LAPs. c Average density of BRCA1 ChIP-seq binding peaks for MCF-10A cells and RAD51 ChIP-seq binding peaks for MCF-7 near HMEC LAPs and recombination HSs