TY - JOUR AU - Kaiser, Vera B. AU - Semple, Colin A. PY - 2018 DA - 2018/07/30 TI - Chromatin loop anchors are associated with genome instability in cancer and recombination hotspots in the germline JO - Genome Biology SP - 101 VL - 19 IS - 1 AB - Chromatin loops form a basic unit of interphase nuclear organization, with chromatin loop anchor points providing contacts between regulatory regions and promoters. However, the mutational landscape at these anchor points remains under-studied. Here, we describe the unusual patterns of somatic mutations and germline variation associated with loop anchor points and explore the underlying features influencing these patterns. SN - 1474-760X UR - https://doi.org/10.1186/s13059-018-1483-4 DO - 10.1186/s13059-018-1483-4 ID - Kaiser2018 ER -