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Fig. 7 | Genome Biology

Fig. 7

From: Selection-driven cost-efficiency optimization of transcripts modulates gene evolutionary rate in bacteria

Fig. 7

A cartoon depicting how selection optimizes both biosynthetic cost and translational efficiency for individual genes. Each circle represents a hypothetical gene sequence. The intensity of the color of the circle is proportional to its mRNA abundance. Low abundance genes experience weak selection and are not optimized for biosynthetic cost or translational efficiency. Highly expressed genes experience strong selection and lie on or near to the Pareto efficient frontier (indicated by a red line). The shaded arrows show the direction that selection will move a gene through this landscape. It is not possible for a gene to occur in the space beyond the Pareto frontier because of the cost-efficiency trade-off

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