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Fig. 6 | Genome Biology

Fig. 6

From: Selection-driven cost-efficiency optimization of transcripts modulates gene evolutionary rate in bacteria

Fig. 6

Selection-driven optimization of resource allocation is a critical factor that determines molecular evolutionary rate. Highly cost-efficiency optimized genes have a higher proportion of deleterious (a) synonymous (y = 1.15x – 8, R2 = 0.81) and (b) non-synonymous (y = 1.71x − 38, R2 = 0.78) mutations. Orthologous genes in Escherichia coli and Salmonella enterica show a negative correlation between sequence cost-efficiency optimization and the rate of (c) synonymous mutations (Ks) (y = − 11x + 61, R2 = 0.26) and (d) non-synonymous mutations (Ka) (y = − 9x + 48, R2 = 0.28). e Histogram of proportion of gene evolutionary rate explained by selection-driven cost-efficiency optimization of transcript sequences

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