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Fig. 4 | Genome Biology

Fig. 4

From: Functional characterization of enhancer evolution in the primate lineage

Fig. 4

Common Patterns of Enhancer Modulation over the Primate Phylogeny. a Functional scores for all enhancer tiles normalized to the MRCA of hominoids and Old World monkeys (N2). Black bar graph in the center contains the N2 score for each tile. Color bars above the heatmap indicate subsets of enhancer tiles exhibiting coherent patterns with respect to gain/loss of activity across the primate phylogeny, including: increased in NWM (yellow), increased in hominoid (gray), decreased in NWM (green), decreased in hominids (orange), and decreased in OWM (purple). b The average score normalized to N2 for each species across the group of 27 enhancer tiles with increased activity restricted to the outgroup of New World monkeys. Gray “+” / “-” indicates that there could be either a gain-of-activity event at the “+” or a loss-of-activity event at the “-”. Error bars are one standard error. c Same as (b) for a group of 22 enhancer tiles with increased activity within the hominoid clade. Red “+” indicates a gain-of-activity event. d Same as (b) for a group of 29 enhancer tiles with decreased activity restricted to the outgroup of New World monkeys. e Same as (b) for a group of 22 enhancer tiles with decreased activity in hominids. Blue “-” indicates a loss-of-activity event. f Same as (b) for a group of 36 enhancer tiles with decreased activity in OWM

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