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Fig. 3 | Genome Biology

Fig. 3

From: Functional characterization of enhancer evolution in the primate lineage

Fig. 3

Functional Scores for Orthologs and Ancestral Sequences. a The average pairwise Spearman correlation of functional scores between any two orthologs across all enhancer tiles tested. b Correlation between the STARR-seq enrichment scores, normalized to the enrichment score of its human ortholog (log2[non-human score/human score]), and gkm-SVM predicted scores, similarly normalized to the predicted score of its human ortholog (log2[non-human prediction/human prediction]). c Functional scores normalized to human for all orthologs of the 220 enhancer tiles. Black bars represent missing data. Clades are denoted by vertical colored lines (green: hominoid, orange: Old World monkeys, purple: New World monkeys). Groups are denoted by horizontal colored lines below the dendrogram; gray: relatively higher activity in in Old World monkeys, orange: relatively lower in Old World monkeys, green: relatively higher activity in either humans or hominoids

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