Fig. 2

Performance of Computational Predictions. a We trained the gapped-kmer support vector machine classifier (gkm-SVM) on an independent reporter assay experiment conducted in HepG2 cells. We then predicted the functional activity of all of our human sequence tiles and found a modest correlation with our functional data. b The distributions of differences in predicted gkm-SVM score between the human vs. marmoset, vervet, or rhesus ortholog for all active human tiles. c Predicted scores for all orthologs of the 348 human-active enhancer tiles, normalized to the human ortholog. Clades are denoted by colored lines (green: hominoid, orange: Old World monkeys, purple: New World monkeys). Cyan bar below dendrogram denotes a group of 108 enhancer tiles that follows expectations for hominoid-specific enhancers as predicted by ChIP-seq comparative genomics