Fig. 5

DNMT3A and TET1 impact each other’s binding on chromatin. a The average occupancy of DNMT3A1 in Bio-Dnmt3a1 and Bio-Dnmt3a1 - Tet1 KO ESCs on TSS-associated TET1 peaks and the flanking 5-kb regions. b Position of hypermethylated DMRs around TSS-associated TET1 peaks, comparing Tet1/2/3 TKO (Tet TKO) [30] and WT ESCs. The normalized TET1 peaks are positioned with 0 representing the peak centers, and positions ± 1 representing the TET1 peak edges, as indicated by the gray bar. c, d The average occupancy of TET1 (anti-FLAG ChIP-seq) in Tet1-FLAG and Tet1-FLAG - Dnmt3a KO ESCs across all TET1 peaks (c) and canyons (d). e Average occupancy of TET1 in Tet1-FLAG and Tet1-FLAG - Dnmt3a KO ESCs and DNMT3A1 in WT (Bio-Dnmt3a1) and Tet1 KO ESCs at genes from each group