Fig. 1
From: DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells
Global DNA methylation in mouse ESCs is predominantly regulated by DNMT3A. a Average genome-wide methylated CpG dinucleotides percentages in WT, Dnmt3a KO, and Dnmt3b KO ESCs. b Violin plots of CpG methylation levels in WT, Dnmt3a KO, and Dnmt3b KO ESCs determined by whole genome bisulfite sequencing (WGBS) at the indicated genomic features. c UCSC genome browser track depicting DNA methylation at the Sox2 locus in WT, Dnmt3a KO, and Dnmt3b KO ESCs. Methylation ratios from 0 to 1 for individual CpG sites are shown. The identified DNA methylation canyon in each line is indicated by a solid colored bar. d, e The number of UMRs (d) and canyons (e) in the indicated lines of ESCs