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Fig. 5 | Genome Biology

Fig. 5

From: Alternative DNA secondary structure formation affects RNA polymerase II promoter-proximal pausing in human

Fig. 5

G4 structures identified by G4-specific antibody in NHEK cells strongly correlate with Pol II pausing sites and free energy minima of computed structures. a Heat map representations of Pol II ChIP-seq (red), and G4 ChIP-seq (black) coverage and free energy (green-red) profile in NHEK cells are shown at the TSS ± 2 knt region. Genes with G4 structures within the TSS + 2 kb region (n = 656) were ordered by the distance of the Pol II ChIP-seq peak summit from each gene’s TSS. b Average G4 structure profiles (black line) and average Pol II ChIP-seq coverage profiles (red line) are generated from the data described in a

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Genome Biology

ISSN: 1474-760X

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