Fig. 2

Robust linear regression analysis of CpG island features across cell types. a Univariate robust linear regression analysis of CpG island features across cell types associated with expression noise. b Multivariate robust linear regression analysis of CpG island features across cell types associated with noise. For both human and mouse cell types, robust linear models were fitted to rCV² for all genes with an associated CpG island. Points that fall above the horizontal line are associated with greater noise, whilst those below are associated with lower. Features for which there is insufficient statistical evidence to reject the null hypothesis of no association with gene expression noise have a lighter shading. Symbols represent the different cell types (circles for α-islets, squares for β-islets, triangles for naive Cd4+ T cells and diamonds for embryonic stem cells). Human and mouse cell types are denoted by colours (blue for human and red for mouse)