Table 1 Genomic context of CpG sites selected for each L-DMR library approach
| Â | Automatic selection 450Â K | Automatic selection EPIC | IDOL EPIC | P a |
|---|---|---|---|---|
Probes | (n = 600) | (n = 600) | (n = 450) |  |
| Â | N(%) | N(%) | N(%) | Â |
CpG present on 450Â K array | 600 (100) | 203 (34) | 140 (31) | 7.50E-29 |
Enhancers (Phantom5) | 53 (9) | 108 (18) | 70 (16) | 3.13E-69 |
DNase hypersensitive sites | 452 (75) | 467 (78) | 328 (73) | 6.66E-147 |
Genomic context | ||||
 CpG island | 47 (8) | 24 (4) | 10 (2) | 4.35E-62 |
 Shores | 116 (19) | 55 (9) | 63 (14) |  |
 Shelves | 95 (16) | 41 (7) | 35 (8) | |
 Open sea | 342 (57) | 480 (80) | 342 (76) | |
Functional context | ||||
 TSS1500 | 73 (12) | 44 (7) | 38 (8) | 2.10E-102 |
 TSS200 | 46 (8) | 23 (4) | 11 (2) |  |
 5′ UTR | 76 (13) | 69 (12) | 46 (10) | |
 First exon | 20 (3) | 16 (3) | 7 (2) | |
 Body | 241 (40) | 283 (47) | 210 (47) | |
 3′ UTR | 29 (5) | 11 (2) | 9 (2) | |
 Intergenic | 115 (19) | 152 (25) | 128 (28) | |