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Table 4 Goodness of fit test for the Poisson and NB models for large-scale datasets on the GemCode and Chromium platforms

From: UMI-count modeling and differential expression analysis for single-cell RNA sequencing

Data

Cells used (n)

Genes tested (n)

Genes reject Poisson (n)

Genes reject NB (n)

Accept Poisson (%)

Reject NB (%)

Naive T cells (Gemcode)

7332

776

403

65

48.07

8.38

Memory T cells (Gemcode)

8622

836

533

28

36.24

3.35

Rh41 (Chromium)

6187

6853

4630

295

32.44

4.30

  1. A model is rejected if FDR < 0.05 among all genes tested; otherwise it is accepted
  2. NB negative binomial