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Fig. 10 | Genome Biology

Fig. 10

From: Vex-seq: high-throughput identification of the impact of genetic variation on pre-mRNA splicing efficiency

Fig. 10

The impact of NMD on Vex-seq splicing results. a Western blot from Wes showing UPF1 knockdown in K562 cells. b A volcano plot showing the significance (assessed by rMATS-STAT) and change in splicing of shUPF1 cells compared to a scrambled control. c A scatter plot showing the behavior of ΔΨ of test exons in which there is a significant difference in the shUPF1 cells compared to the shScrambled cells. The color coding highlights test exons in which a significant difference in Ψ was identified. d Violin plots showing the predicted impact of NMD on variants which would be subject to NMD endogenously, but not in Vex-seq

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