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Fig. 6 | Genome Biology

Fig. 6

From: RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

Fig. 6

Imbalanced m6A RNA methylation in the cerebellum of Alkbh5-deficient mouse exposed to hypobaric hypoxia. a Boxplots showing the relative methylation levels of all m6A peaks between wild-type (WT) and Alkbh5-deficient (KO) mouse cerebellum. ***P < 0.001 by Wilcoxon test. b Venn diagram showing the relationship among the RNAs containing gain-of-methylation (Gain), lost-of-methylation (Loss), and differentially methylated RNAs (DMRs). c, d GO analysis of genes encoded by RNAs containing loss- (c) or gain-of-methylation (d) in KO mouse cerebellum. BP biological process, CC cellular component. e Gene-specific m6A-IP-qPCR results showing the relative methylation levels of four RNAs in the cerebellum of KO mice compared to those in WT mice. n = 7. f Subcellular localization of the four RNAs as shown by the ratio of RNA abundance between the cytoplasmic and nuclear fractions isolated from the cerebellum of WT and KO mice. n = 10 for WT and 8 or 10 for KO, respectively. *P < 0.05, **P < 0.01, ns not significant

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