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Fig. 2 | Genome Biology

Fig. 2

From: RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum

Fig. 2

Distinct features of temporal-specific m6A methylation during postnatal development of the mouse cerebellum. a Venn diagram showing the numbers and relationship of methylated poly(A) RNAs in the mouse cerebellum from P7 to P60. b IGV plots showing examples of continuous and temporally specific methylation. Grey reads originate from input libraries and red reads originate from m6A-IP libraries. Y-axis represents normalized numbers of read counts. Arrows indicate the direction of gene transcription. Dashed boxes indicate the position of temporal-specific m6A peaks. c Box plots showing the relative methylation levels of SMRs and CMRs as evaluated by the enrichment scores of m6A peaks. SMR specifically methylated RNA, CMR continuously methylated RNA. ***P < 0.001 by Wilcoxon test. d Normalized distribution of temporal-specific m6A peaks in each developmental stage along the whole mRNA transcripts. e, f Most impacted GO biological process terms (BP) (e) and cellular component terms (CC) (f) of SMRs in the four developmental stages

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