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Table 1 Genes under significant selection

From: Negative selection in tumor genome evolution acts on essential cellular functions and the immunopeptidome

Gene name dN/dS Q value
AP2S1 0.043 0.0107
BCL2L12 a 0.093 0.0001
RALBP1 0.121 0.0738
CLDN9 0.126 0.0625
GTSF1L b 0.178 0.0501
ZDHHC3 0.255 0.0625
DECR1 0.286 0.0341
HLA-DOA 0.291 0.0581
TMEM214 0.328 0.0408
GRID2IP a 0.331 0.0107
DAGLB 0.338 0.0241
GFRA3 0.351 0.0532
TERT 0.368 0.0007
KRI1 0.372 0.0408
ZBTB7C 0.379 0.0073
NPSR1 0.404 0.0241
AP1B1 0.41 0.0387
WISP1 0.421 0.0408
MCM2 0.434 0.0581
XKR6 0.471 0.0802
CYFIP1 0.475 0.0317
TYK2 0.521 0.0802
EPPK1 0.591 0.0073
CACNA1S 0.625 0.0632
TECTA b 0.626 0.0209
FGFR2 2.36 0.0802
ERBB3 2.523 0.0428
KEAP1 2.701 0.048
CTNNB1 3.344 0
SMAD4 3.976 0.0387
PTEN 4.756 0
FBXW7 5.577 0
HRAS 5.636 0.0802
PIK3CA 5.928 0
SPOP 6.89 0.0016
BRAF 9.782 0
TP53 10.304 0
IDH1 21.589 0
KRAS 25.681 0
  1. Genes with dN/dS < 1 are under negative selection
  2. aGenes with signals of negative selection potentially influenced by germline variants or positive selection on silent mutations: GRID2IP has 17 synonymous somatic mutations having an EXAC allele frequency > 0.001, BCL2L12 has a silent mutation cluster.
  3. bNot significant after removing non-diploid regions