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Fig. 7 | Genome Biology

Fig. 7

From: Histone H4 acetylation regulates behavioral inter-individual variability in zebrafish

Fig. 7

Conservation between epigenomic and transcriptomic results. a Workflow of the RNA-seq analysis of control and NaBu-treated samples. b The density of the gene expression ratio (NaBu normalized counts divided by control normalized counts) in the genes located near acH4 candidate peaks (blue) and genes not located near acH4 candidate peaks (red). c Gene expression fold change differences in eight selected genes in AB, NaBu-treated, hdac1 +/−, and yy1 +/− larvae. Normalization was made by subtracting the values obtained for the gapdh gene in each sample, and bars mark standard deviation obtained from three replicates. d Same as c but comparing samples with different distance r to the average behavior of the population. e Enriched Gene Ontology terms found in the set of genes over-expressed after NaBu treatment. f Same as e but for genes down-regulated after NaBu treatment. g Schematic model of the results obtained in the manuscript. In control conditions, heterogeneous populations as classified by their activity and radial index were obtained. After alteration of the YY1/HDAC1 pathway, more homogeneous populations were observed, while the acH4 content and the YY1/HDAC1 presence in a set of genomic regions were anti-correlated, these epigenetic changes being transferred to the gene expression level

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