Skip to main content
Fig. 10 | Genome Biology

Fig. 10

From: Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Fig. 10

Distinct non-CpG methylation patterns in GSC and NSC. a Bar graph demonstrating the total number of highly modified CpT, CpA, and CpC sites in each cell line. b ChromHMM model illustrating the co-localization of non-CpG methylation changes among NSC and GSC lines. Enrichment level for co-localization increases as color migrates from light blue to dark blue. A heatmap depicting histone marks and states formed by different combinations is shown at the left. A region of interest discussed in the results section is marked with a red box. c Stacked bar graph showing gained and lost non-CpG methylation events, noted by the numbers in each bar, in NSCs and GSCs in response to differentiation cues. Blue: gain; green: loss. Cell line types and the differentiation condition are labeled on the X-axis. ADM astrocytic induction of NSC27, NDM neuronal induction of NSC27. GSC6/64/84: FBS induction. d Bar graph illustrating enrichment of differential non-CpG methylation events induced by differentiation of NSC and GSC lines. Top: hypermethylation events. Bottom: hypomethylation events. X-axis: genomic feature. Y-axis: percent enrichment by normalizing to the total number of non-CpGs associated with each feature. e Correlation of differentiation-induced non-CpG methylation changes in NSC and GSC. Blue: positive correlation; orange: negative correlation. Dot size represents the magnitude of correlation. Samples within the same box are most correlated with each other. f Venn diagrams illustrating the overlap of hyper- (top) and hypo- (bottom) non-CpG methylation events between astrocytic and neuronal differentiation induction conditions for NSC27. g Venn diagrams illustrating the overlap of hyper- (left) and hypo- (right) non-CpG methylation events in FBS-induced differentiation conditions for GSC6, GSC64, and GSC84

Back to article page