Fig. 1

Global patterns of single-cell expression profiles and the identification of cell types. a Schematic of the sampling position (left) and sampling information (right) of each mouse organ and tissue. b Regulon matrix-based t-distributed stochastic neighbor embedding (t-SNE) plot showing the origin and embryonic stage of the cells. Organ types are indicated by colors, and developmental stages are indicated by shapes. The major groups identified are circled and annotated. c Hierarchical clustering through the regulon matrix showing the relationships of cells sampled from different organs and major groups identified by the regulon matrix. d Heatmaps showing the top 10 group-specific transcription factors (TFs, left) and differentially expressed genes (DEGs, right) of each major group. The color key from blue to red indicates low to high gene expression or TF activity, respectively