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Fig. 7 | Genome Biology

Fig. 7

From: The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts

Fig. 7

WFDC1 and IL-17D correlate with a tumor-suppressive immune profile in ovarian cancer patients. a Heatmap of immune-related genes significantly co-expressed (P = 0.01) with SORBS2, showing log2 expression Z scores for 20% of samples with highest or lowest SORBS2 expression. b Correlation data for SORBS2 versus WFDC1 expression in TCGA dataset. The statistical significance of correlations was determined using Pearson’s correlation coefficient. c Correlation data for SORBS2 versus IL-17D expression in TCGA dataset. The linear regression curve is shown as a black line for significant correlations. d As in a for 50% of samples with the highest or lowest combined SORBS2 and WFDC1 expression. e As in b for samples with highest or lowest combined SORBS2 and IL-17D expression

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Genome Biology

ISSN: 1474-760X

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