Fig. 6

SORBS2 recognizes and stabilizes these metastasis-suppressive transcripts via its ZnF_C2H2 domain. a SORBS2 with its binding domains and the respective mutants. b Transwell invasion assays were performed in control A2780s cells and A2780s cells with enforced expression of WT SORBS2, ∆SoHo, ∆SH3, and ∆Znf plasmids. c Peritoneal metastatic nodule number in mice inoculated with control A2780s cells and A2780s cells with enforced expression of WT SORBS2, ∆SoHo, ∆SH3, and ∆Znf plasmids 4 weeks post-inoculation. d Ascites volume in mice inoculated with control A2780s cells and A2780s cells with enforced expression of WT SORBS2, ∆SoHo, ∆SH3, and ∆Znf plasmids 4 weeks post-inoculation. e Relative mRNA levels of WFDC1 in control A2780s cells and A2780s cells with enforced expression of WT SORBS2, ∆SoHo, ∆SH3, and ∆Znf plasmids. f Relative mRNA levels of IL-17D in control A2780s cells and A2780s cells with enforced expression of WT SORBS2, ∆SoHo, ∆SH3, and ∆Znf plasmids. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01