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Fig. 5 | Genome Biology

Fig. 5

From: The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts

Fig. 5

SORBS2 knockdown-induced enhanced ovarian cancer metastasis can be reversed by enforced expression of WFDC1 and IL-17D alone or combined. a Immunohistochemistry analysis of WFDC1 and IL-17D expression in SORBS2-low and SORBS2-high metastatic tissues of ovarian cancer. b WFDC1 and IL-17D expression at different clinical stages of ovarian cancer in the Oncomine database. c WFDC1, IL-17D, and a combination of WFDC1 and IL-17D were stably overexpressed in shSORBS2 A2780s cells. Transwell chamber assays were performed with these cells. d WFDC1, IL-17D, and a combination of WFDC1 and IL-17D were stably overexpressed in SORBS2-depleted A2780s cells. Wound healing assays were performed with these cells. e Representative photographs of peritoneal metastasis of WFDC1-overexpressed, IL-17D-overexpressed and, WFDC1/IL-17D-overexpressed SORBS2-depleted A2780s ovarian cancer cells compared with control SORBS2-depleted A2780s cells and shCTRL-treated A2780s cells 4 weeks post-inoculation. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001

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