Skip to main content
Fig. 4 | Genome Biology

Fig. 4

From: The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts

Fig. 4

SORBS2 depletion destabilizes transcripts of WFDC1 and IL-17D, which are correlated with clinical outcome in ovarian cancer. a qRT-PCR of WFDC1 and IL-17D in control A2780s and control SKOV-3 ovarian cancer cells and SOBRS2-depleted A2780s and SKOV-3 ovarian cancer cells at 0 and 9 h after α-amanitin treatment. 18S was used as an endogenous control. b qRT-PCR of WFDC1 and IL-17D in A2780s shSORBS2 and shCTRL cells at the times indicated after treatment of cells with DRB. c Kaplan-Meier curve showing overall survival of ovarian cancer patients with tumors expressing high (red) or low (black) levels of WFDC1 and IL-17D. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001

Back to article page