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Fig. 3 | Genome Biology

Fig. 3

From: The RNA binding protein SORBS2 suppresses metastatic colonization of ovarian cancer by stabilizing tumor-suppressive immunomodulatory transcripts

Fig. 3

SORBS2 depletion affects the stability of transcripts directly bound by SORBS2. a Distribution of SORBS2 RIP sequencing peak annotation for different regions. b Venn diagram of transcripts stabilized and bound by SORBS2. Transcripts bound by SORBS2 in the RIP sequencing data (n = 1084), transcripts with steady state levels downregulated in shSORBS2 versus control cells (n = 708; fold change down > 1.1 in shSORBS2 vs shCTRL, q < 0.05), and transcripts destabilized upon SORBS2 knockdown (n = 2560; fold change down > 1.1 after α-amanitin treatment in shSORBS2 vs control cells). c Pie chart showing the subcellular locations of proteins translated by SORBS2-stabilized transcripts. d Genes encoding secreting proteins translated by SORBS2-stabilized transcripts

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Genome Biology

ISSN: 1474-760X

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