Fig. 4

Comparison of predicted and BLESS double-strand breaks (DSBs) and validation with an independent dataset. a Comparison for the MYC and MAP2K3 genes. b Venn diagram illustrating the overlaps between DSBCapture, random forest DSBCapture-trained model predictions, and BLESS DSBs. c Venn diagram illustrating the overlaps between DSBCapture, random forest BLESS-trained model predictions, and BLESS DSBs. d Comparison of receiver operating characteristic (ROC) curves between DSBCapture-trained and BLESS-trained models. Areas under the ROC curves (AUROCs) are plotted. e ROC curve for the prediction of DSBs trained on replicate 1 and tested on the same replicate. f ROC curve for the prediction of DSBs trained on replicate 1 and tested on replicate 2. AUROC area under the ROC curve, DSB double-strand break, ROC receiver operating characteristic