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Fig. 3 | Genome Biology

Fig. 3

From: Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species

Fig. 3

a A bean plot of the methylation levels for CpG Islands (Isl.) and Open Sea (OS) for both probes matching mouse genome and those uniquely mapping to human chromosome 21. b A bean plot of the methylation levels for promoters (P) (defined as 2 kbp upstream from the TSS), gene bodies (B) and intergenic regions (I) (defined as those probes not either in a promoter or gene body). This is shown for both probes matching mouse genome and those uniquely mapping to human chromosome 21. c A scatter plot of the gradients of human chromosome 21 aDMPs in both human samples and the TC1 mouse. There is a significant correlation of 0.49 (P value = 0.011). Highlighted in red are the probes which show the largest gradient in the TC1 mouse. d A scatter plot showing the increased rate of methylation change with respect to age in the human chromosome 21 aDMPs in the Tc1 mouse compared to the same aDMP in human samples

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