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Fig. 6 | Genome Biology

Fig. 6

From: Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys

Fig. 6

A model for the role of Polycomb in maintenance of DMV hypomethylation. Polycomb-targeted DMVs have lower nucleosome occupancy and higher CG density than their surrounding regions. They tend to form insulated structures from their surrounding methylated regions. In WT mESCs, Polycomb maintains DMV hypomethylation in non-CGI regions, likely through recruiting TETs. The absence of Polycomb leads to increase of DNA methylation in non-CGI regions and also increase of H3K27ac in CGI regions [56]. Genes near DMVs remain silenced during this process. CGIs in DMVs are maintained DNA methylation-free, presumably due to additional protection mechanisms including H3K4me3

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Genome Biology

ISSN: 1474-760X

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